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apoa1 mimetics  (Mimetics)

 
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    Mimetics apoa1 mimetics
    Apoa1 Mimetics, supplied by Mimetics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/apoa1 mimetics/product/Mimetics
    Average 86 stars, based on 1 article reviews
    apoa1 mimetics - by Bioz Stars, 2026-06
    86/100 stars

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    Mechanism by which <t>ApoA1</t> Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com
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    Mechanism by which <t>ApoA1</t> Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com
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    Mechanism by which <t>ApoA1</t> Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com
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    Mechanism by which ApoA1 Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com

    Journal: Critical Care

    Article Title: ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review

    doi: 10.1186/s13054-025-05668-1

    Figure Lengend Snippet: Mechanism by which ApoA1 Inhibits Vascular Endothelial Inflammation. Lipid-free ApoA1 protein or its mimetic peptides interact with the ABCA1 receptor (a 12-transmembrane protein located in non-raft membrane domains, which has poor cholesterol) on macrophages. Concurrently, ApoA1 within (r)HDL interacts with the scavenger receptor SR-B1 (located in cholesterol-rich lipid raft domains). Both interactions promote the efflux of free cholesterol from macrophages to ApoA1 (indicated by a yellow straight arrow). Notably, the cholesterol efflux regulatory protein AIBP (ApoA1-Binding Protein) enhances the binding of ApoA1 to the ABCA1 receptor. Pathway ①: Inhibition of TLR4 consequently suppresses its downstream pro-inflammatory signaling pathways. Pathways ② and ③: Signaling pathways that inhibit inflammation, initiated respectively by the binding of ApoA1 to the ABCA1 receptor and HDL to the SR-B1 receptor. Pathway ④: Reconstituted HDL (rHDL) inhibits LPS-stimulated activation of the NLRP3 inflammasome. Created with BioGDP.com

    Article Snippet: APOA1 mimetic peptide 4 F , In vivo , Sprague - Dawley rats , 10 mg/kg; i.p. , CLP , , IL-6↓;HDL↑; survival rate↑ , [ ] .

    Techniques: Membrane, Binding Assay, Inhibition, Protein-Protein interactions, Activation Assay

    ApoA1 maintains endothelial barrier integrity. Pathway ①: ApoA1 and ApoA1 mimetic peptides (such as D-4 F) inhibit EndMT in endothelial cells. Pathway ②: (r)HDL binds to the SR-B1 receptor, initiating signaling pathways that upregulate ANGPTL4 levels, thereby protecting the endothelial glycocalyx. Created with BioGDP.com

    Journal: Critical Care

    Article Title: ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review

    doi: 10.1186/s13054-025-05668-1

    Figure Lengend Snippet: ApoA1 maintains endothelial barrier integrity. Pathway ①: ApoA1 and ApoA1 mimetic peptides (such as D-4 F) inhibit EndMT in endothelial cells. Pathway ②: (r)HDL binds to the SR-B1 receptor, initiating signaling pathways that upregulate ANGPTL4 levels, thereby protecting the endothelial glycocalyx. Created with BioGDP.com

    Article Snippet: APOA1 mimetic peptide 4 F , In vivo , Sprague - Dawley rats , 10 mg/kg; i.p. , CLP , , IL-6↓;HDL↑; survival rate↑ , [ ] .

    Techniques: Protein-Protein interactions

    ApoA1 prevents vascular occlusion, thrombosis, and maintains vascular tone. Pathway ①: (r)HDL binds to the PDZK1 domain of SR-B1, leading to eNOS phosphorylation, producing NO to prevent microvascular occlusion and reducing vWF. Pathway ②: Lipid-free ApoA1 or (r)HDL binds to Ecto-F1-ATPase, activating the PI3Kβ/AKT signaling pathway. Pathway ③ and ④ upregulate COX-2 and PGI-2. Created with BioGDP.com

    Journal: Critical Care

    Article Title: ApoA1/HDL and sepsis-associated vascular endothelial injury: a narrative review

    doi: 10.1186/s13054-025-05668-1

    Figure Lengend Snippet: ApoA1 prevents vascular occlusion, thrombosis, and maintains vascular tone. Pathway ①: (r)HDL binds to the PDZK1 domain of SR-B1, leading to eNOS phosphorylation, producing NO to prevent microvascular occlusion and reducing vWF. Pathway ②: Lipid-free ApoA1 or (r)HDL binds to Ecto-F1-ATPase, activating the PI3Kβ/AKT signaling pathway. Pathway ③ and ④ upregulate COX-2 and PGI-2. Created with BioGDP.com

    Article Snippet: APOA1 mimetic peptide 4 F , In vivo , Sprague - Dawley rats , 10 mg/kg; i.p. , CLP , , IL-6↓;HDL↑; survival rate↑ , [ ] .

    Techniques: Phospho-proteomics